Targeting of Tumor-Associated Glycoforms of MUC1 with CAR T Cells

We read with interest the manuscript by June and colleagues published recently in Immunity in which they describe targeting of aberrantly glycosylated tumor-associated cell membrane mucin MUC1 using chimeric antigen receptor-engineered human T cells (Posey et al., 2016Posey Jr., A.D. Schwab R.D. Boesteanu A.C. Steentoft C. Mandel U. Engels B. Stone J.D. Madsen T.D. Schreiber K. Haines K.M. et al.Engineered CAR T Cells Targeting the...