ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
Abstract
Ferroptosis is a form of regulated necrotic cell death controlled by glutathione peroxidase 4 (GPX4). At present, mechanisms that could predict sensitivity and/or resistance and that may be exploited to modulate ferroptosis are needed. We applied two independent approaches-a genome-wide CRISPR-based genetic screen and microarray analysis of ferroptosis-resistant cell lines-to uncover acyl-CoA synthetase long-chain family member 4 (ACSL4) as an...
Paper Details
Title
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
Published Date
Nov 14, 2016
Journal
Volume
13
Issue
1
Pages
91 - 98
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