Serine Synthesis Helps Hypoxic Cancer Stem Cells Regulate Redox
Abstract
Phosphoglycerate dehydrogenase (PHGDH) is the metabolic enzyme responsible for shunting the glycolytic intermediate 3-phosphoglycerate to the serine synthesis pathway. In breast cancer and several other types of cancer, increased PHGDH expression is associated with patient mortality. Early studies focused on the role of PHGDH in promoting cell proliferation in the small percentage of breast cancers with PHGDH gene amplification. However, recent...
Paper Details
Title
Serine Synthesis Helps Hypoxic Cancer Stem Cells Regulate Redox
Published Date
Nov 14, 2016
Journal
Volume
76
Issue
22
Pages
6458 - 6462
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