Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma

Nature64.80
Volume: 539, Issue: 7628, Pages: 309 - 313
Published: Nov 10, 2016
Abstract
Although human tumours are shaped by the genetic evolution of cancer cells, evidence also suggests that they display hierarchies related to developmental pathways and epigenetic programs in which cancer stem cells (CSCs) can drive tumour growth and give rise to differentiated progeny. Yet, unbiased evidence for CSCs in solid human malignancies remains elusive. Here we profile 4,347 single cells from six IDH1 or IDH2 mutant human...
Paper Details
Title
Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma
Published Date
Nov 10, 2016
Journal
Volume
539
Issue
7628
Pages
309 - 313
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