Isomeric separation of cannabinoids by UPLC combined with ionic mobility mass spectrometry (TWIM-MS)—Part I

The Cannabis sativa L. plant is rich in a wide variety of cannabinoids. Δ9–tetrahydrocannabinol (Δ9–THC) is the main chemical compound responsible for its psychoactive effect, and it can be identified as [M+H]+ and [M-H]− ions at m/z 315 and 313, respectively, where M = C21H30O2. However, six other isomeric or isobaric forms of Δ9–THC can exist, which makes its unequivocal characterization a challenge. In this work, ultra-high liquid...