Advances in structure-based drug discovery of carbonic anhydrase inhibitors
Abstract
The enzyme carbonic anhydrase (CA, EC 4.2.1.1) is found in numerous organisms across the tree of life, with seven distinct classes known to date. CA inhibition can be exploited for the treatment of edema, glaucoma, seizures, obesity, cancer and infectious diseases. A myriad of CA inhibitor (CAI) classes and inhibition mechanisms have been identified over the past decade, mainly through structure-based drug design approaches. Five different CA...
Paper Details
Title
Advances in structure-based drug discovery of carbonic anhydrase inhibitors
Published Date
Nov 9, 2016
Volume
12
Issue
1
Pages
61 - 88
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