Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease
Abstract
In inflammation-associated progressive neuroinflammatory disorders, such as multiple sclerosis (MS), inflammatory infiltrates containing T helper 1 (TH1) and TH17 cells cause demyelination and neuronal degeneration. Regulatory T cells (Treg) control the activation and infiltration of autoreactive T cells into the central nervous system (CNS). In MS and experimental autoimmune encephalomyelitis (EAE) in mice, Treg function is impaired. We show...
Paper Details
Title
Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease
Published Date
Oct 26, 2016
Volume
8
Issue
362
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