Melatonin rescues cardiac thioredoxin system during ischemia‐reperfusion injury in acute hyperglycemic state by restoring N otch1/H es1/A kt signaling in a membrane receptor‐dependent manner
Abstract
Stress hyperglycemia is commonly observed in patients suffering from ischemic heart disease. It not only worsens cardiovascular prognosis but also attenuates the efficacies of various cardioprotective agents. This study aimed to investigate the protective effect of melatonin against myocardial ischemia‐reperfusion ( MI /R) injury in acute hyperglycemic state with a focus on Notch1/Hes1/Akt signaling and intracellular thioredoxin (Trx) system....
Paper Details
Title
Melatonin rescues cardiac thioredoxin system during ischemia‐reperfusion injury in acute hyperglycemic state by restoring N otch1/H es1/A kt signaling in a membrane receptor‐dependent manner
Published Date
Oct 18, 2016
Journal
Volume
62
Issue
1
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