DARS: a phase III randomised multicentre study of dysphagia- optimised intensity- modulated radiotherapy (Do-IMRT) versus standard intensity- modulated radiotherapy (S-IMRT) in head and neck cancer

Published on Oct 6, 2016in BMC Cancer3.15
· DOI :10.1186/S12885-016-2813-0
Imran Petkar6
Estimated H-index: 6
(The Royal Marsden NHS Foundation Trust),
Keith Rooney6
Estimated H-index: 6
(Belfast Health and Social Care Trust)
+ 14 AuthorsChristopher M. Nutting69
Estimated H-index: 69
(The Royal Marsden NHS Foundation Trust)
Background Persistent dysphagia following primary chemoradiation (CRT) for head and neck cancers can have a devastating impact on patients’ quality of life. Single arm studies have shown that the dosimetric sparing of critical swallowing structures such as the pharyngeal constrictor muscle and supraglottic larynx can translate to better functional outcomes. However, there are no current randomised studies to confirm the benefits of such swallow sparing strategies. The aim of Dysphagia/Aspiration at risk structures (DARS) trial is to determine whether reducing the dose to the pharyngeal constrictors with dysphagia-optimised intensity- modulated radiotherapy (Do-IMRT) will lead to an improvement in long- term swallowing function without having any detrimental impact on disease-specific survival outcomes.
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