Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling

Ruth Pidsley; Elena Zotenko; Tim J Peters; Mitchell G. Lawrence; Gail P. Risbridger; Peter L. Molloy; Susan Van Djik; Beverly S. Muhlhausler; Clare Stirzaker; Susan J. Clark

doi:https://doi.org/10.1186/s13059-016-1066-1

doi.org/10.1186/s13059-016-1066-1

Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling

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..., Susan J. Clark

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Genome Biology12.30

Volume: 17, Issue: 1

Published: Oct 7, 2016

Abstract

In recent years the Illumina HumanMethylation450 (HM450) BeadChip has provided a user-friendly platform to profile DNA methylation in human samples. However, HM450 lacked coverage of distal regulatory elements. Illumina have now released the MethylationEPIC (EPIC) BeadChip, with new content specifically designed to target these regions. We have used HM450 and whole-genome bisulphite sequencing (WGBS) to perform a critical evaluation of the new...

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Paper Details

Title

Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling

DOI

doi.org/10.1186/s13059-016-1066-1

Published Date

Oct 7, 2016

Journal

Genome Biology

Volume

17

Issue

1

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