ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation
Abstract
Heat shock protein (Hsp)70 is a molecular chaperone that maintains protein homoeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. However, the mechanisms by which Hsp70 balances these opposing functions under stress conditions remain unknown. Here, we demonstrate that Hsp70 preferentially facilitates protein refolding after stress, gradually switching to protein degradation via a mechanism...
Paper Details
Title
ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation
Published Date
Oct 6, 2016
Journal
Volume
7
Issue
1
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