Combination of tauroursodeoxycholic acid and N‐acetylcysteine exceeds standard treatment for acetaminophen intoxication
Abstract
Background & Aims Acetaminophen overdose in mice is characterized by hepatocyte endoplasmic reticulum stress, which activates the unfolded protein response, and centrilobular hepatocyte death. We aimed at investigating the therapeutic potential of tauroursodeoxycholic acid, a hydrophilic bile acid known to have anti‐apoptotic and endoplasmic reticulum stress‐reducing capacities, in experimental acute liver injury induced by acetaminophen...
Paper Details
Title
Combination of tauroursodeoxycholic acid and N‐acetylcysteine exceeds standard treatment for acetaminophen intoxication
Published Date
Oct 25, 2016
Journal
Volume
37
Issue
5
Pages
748 - 756
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Notes
History