Evidence for Pro-angiogenic Functions of VEGF-Ax
Abstract
The VEGF-A isoforms play a crucial role in vascular development, and the VEGF signaling pathway is a clinically validated therapeutic target for several pathological conditions. Alternative mRNA splicing leads to the generation of multiple VEGF-A isoforms, including VEGF165. A recent study reported the presence of another isoform, VEGF-Ax, arising from programmed readthrough translation. Compared to VEGF165, VEGF-Ax has a 22-amino-acid extension...
Paper Details
Title
Evidence for Pro-angiogenic Functions of VEGF-Ax
Published Date
Sep 1, 2016
Journal
Volume
167
Issue
1
Pages
275 - 284.e6
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