Cerebrospinal Fluid Pressure and Trans-lamina Cribrosa Pressure Difference in Open-angle Glaucoma: KNHANES V.

Published on Sep 1, 2016in Journal of The Korean Ophthalmological Society
· DOI :10.3341/JKOS.2016.57.9.1392
Yoon Kyung Kim5
Estimated H-index: 5
(SCH: Soonchunhyang University),
Undarmaa Tumurbaatar1
Estimated H-index: 1
(SCH: Soonchunhyang University)
+ 2 AuthorsKa Hee Park3
Estimated H-index: 3
(SCH: Soonchunhyang University)
김윤경1⋅Undarmaa Tumurbaatar1⋅온영훈1⋅하승주2⋅박가희1 Yoon Kyung Kim, MD, Undarmaa Tumurbaatar, MD, Young-Hoon Ohn, MD, PhD, Seung Joo Ha, MD, PhD, Ka Hee Park, MD 순천향대학교 의과대학 부천병원 안과학교실, 순천향대학교 의과대학 서울병원 안과학교실 Department of Ophthalmology, Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea Department of Ophthalmology, Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea
#1Jost B. Jonas (Capital Medical University)H-Index: 152
#2Ningli Wang (Capital Medical University)H-Index: 56
Last. Liang Xu (Capital Medical University)H-Index: 76
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Purpose To examine whether an estimated trans-lamina cribrosa pressure difference (TLCPD) better than intraocular pressure (IOP) correlated with markers for glaucoma. Methods The population-based Beijing Eye Study 2011 included 3468 individuals. Cerebrospinal fluid pressure (CSFP) was calculated as CSFP [mmHg] = 0.44 × Body Mass Index [kg/m2] + 0.16 × Diastolic Blood Pressure [mmHg] − 0.18 × Age [Years] − 1.91. TLCPD was IOP–CSFP. Results In the non-glaucomatous population, mean TLCPD was 5.8 ± ...
42 CitationsSource
#1Ya Xing Wang (Capital Medical University)H-Index: 31
#2Jost B. Jonas (Capital Medical University)H-Index: 152
Last. Liang Xu (Capital Medical University)H-Index: 76
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Purpose To examine a potential association between intraocular pressure (IOP) and cerebrospinal fluid pressure (CSFP) in a population-based setting.
12 CitationsSource
#1Brian MarekH-Index: 2
#2Alon HarrisH-Index: 72
Last. Brent SieskyH-Index: 28
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Increased trans-lamina cribrosa pressure difference (TLCPD), the difference of intraocular pressure (IOP) and orbital cerebrospinal fluid pressure (CSF-P), has been investigated as a possible risk factor in glaucoma pathogenesis. In fact, lower CSF-P in the setting of normal IOP has been implicated as a potential risk factor for normal tension glaucoma. Increased TLCPD has been associated with decreased neuroretinal rim area and increased visual field defects. Furthermore, dysregulation of syste...
32 CitationsSource
#1Giovanna Guidoboni (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 19
#2Alon HarrisH-Index: 72
Last. Brent SieskyH-Index: 28
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Retinal hemodynamics plays a crucial role in the pathophysiology of several ocular diseases. There are clear evidences that the hemodynamics of the central retinal artery (CRA) is strongly affected by the level of intraocular pressure (IOP), which is the pressure inside the eye globe. However, the mechanisms through which this occurs are still elusive. The main goal of this paper is to develop a mathematical model that combines the mechanical action of IOP and the blood flow in the CRA to elucid...
31 CitationsSource
#1Jost B. Jonas (Heidelberg University)H-Index: 152
#2Vinay Nangia (Heidelberg University)H-Index: 10
Last. Songhomitra Panda-JonasH-Index: 53
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Purpose To assess associations of the trans-lamina cribrosa pressure difference (TLCPD) with glaucomatous optic neuropathy. Methods The population-based Central India Eye and Medical Study included 4711 subjects. Based on a previous study with lumbar cerebrospinal fluid pressure (CSFP) measurements, CSFP was calculated as CSFP[mmHg] = 0.44 Body Mass Index[kg/m2]+0.16 Diastolic Blood Pressure[mmHg]−0.18×Age[Years] −1.91. TLCPD was IOP–CSFP. Results Mean TLCPD was 3.64±4.25 mm Hg in the non-glauco...
54 CitationsSource
#1Xiaobin Xie (Capital Medical University)H-Index: 14
#2Xiaojun Zhang (Capital Medical University)H-Index: 26
Last. Ningli Wang (Capital Medical University)H-Index: 56
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Introduction The orbital subarachnoid space surrounding the optic nerve is continuous with the circulation system for cerebrospinal fluid (CSF) and can be visualized by using magnetic resonance imaging (MRI). We hypothesized that the orbital subarachnoid space width (OSASW) is correlated with and can serve as a surrogate for intracranial pressure (ICP). Our aim was to develop a method for a noninvasive measurement of the intracranial CSF-pressure (CSF-P) based on MRI-assisted OSASW.
87 CitationsSource
#1Kyung Chul Yoon (Chonnam National University)H-Index: 23
#2Gui Hyeong Mun (Chonnam National University)H-Index: 5
Last. Se Woong Kang (SMC: Samsung Medical Center)H-Index: 25
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Epidemiological studies provide information on the prevention, treatment, and minimization of the impact of diseases on society. In the past two decades, a wide range of epidemiologic studies in ophthalmology have provided important information on the pattern of visual impairment and the major eye diseases that cause such vision loss [1]. Although several epidemiological studies of several age-related eye diseases (e.g., glaucoma, age-related macular degeneration, and cataract) have been conduct...
183 CitationsSource
#1J. Crawford Downs (Legacy Health)H-Index: 43
#2Michael D. Roberts (Legacy Health)H-Index: 13
Last. Ian A. Sigal (Legacy Health)H-Index: 38
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The purpose of this review is to examine the literature in an attempt to elucidate a biomechanical basis for glaucomatous cupping. In particular, this work focuses on the role of biomechanics in driving connective tissue remodeling in the progression of laminar morphology from a normal state to that of an excavated glaucomatous state. While there are multiple contributing factors to the pathogenesis of glaucoma, we focus on laminar extracellular matrix (ECM) remodeling in glaucoma and the feedba...
150 CitationsSource
#1Chang-Sik Kim (CNU: Chungnam National University)H-Index: 14
#2Gong Je Seong (Yonsei University)H-Index: 34
Last. Ki-chul SongH-Index: 1
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Purpose To assess the prevalence of primary open-angle glaucoma (POAG) in the Namil-myon area in central South Korea. Design A cross-sectional, epidemiologic study in a defined population. Participants Residents aged ≥40 years in Namil-myon, a rural agricultural area in central South Korea. Methods Each subject underwent a screening that consisted of an interview and ophthalmic examinations, including visual acuity measurement, autorefraction, anterior segment evaluation by optical biometry, sli...
221 CitationsSource
#1Ruojin Ren (Capital Medical University)H-Index: 11
#2Jost B. Jonas (Capital Medical University)H-Index: 152
Last. Ningli Wang (Capital Medical University)H-Index: 56
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Purpose To assess whether a low cerebrospinal fluid pressure (CSF-P) is associated with open-angle glaucoma in eyes with normal intraocular pressure (IOP). Design Prospective, interventional study. Participants The study included 43 patients with open-angle glaucoma (14 with a normal IOP, and 29 with an elevated IOP) and 71 subjects without glaucoma. Interventions All patients underwent standardized ophthalmologic and neurologic examinations and measurement of lumbar CSF-P. Main Outcome Measures...
363 CitationsSource
Cited By3
#1Suk Hoon Jung (Catholic University of Korea)H-Index: 2
#2Soo Ji Jeon (Catholic University of Korea)H-Index: 7
Last. Hae Young Lopilly Park (Catholic University of Korea)H-Index: 2
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#1Seung Kwan Nah (SCH: Soonchunhyang University)H-Index: 3
#2Young-Hoon Ohn (SCH: Soonchunhyang University)H-Index: 9
Last. Si Hyung Lee (SCH: Soonchunhyang University)H-Index: 7
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#1Ji Young Lee (Catholic University of Korea)H-Index: 3
#2Hye Bin Yim (Catholic University of Korea)H-Index: 7
Last. Na Young Lee (Catholic University of Korea)H-Index: 7
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