Preparation of novel ring-A fused azole derivatives of betulin and evaluation of their cytotoxicity
Abstract
An efficient scheme to synthesize novel ring-A fused heterocyclic derivatives of betulin was developed. The starting reaction of this synthesis was one-pot selective bacterial oxidation of betulin to betulone used as the key compound to synthesize the substituted azoles such as C(2)-C(3)-fused 1,2,3-triazoles, oxazoles and 1,2,4-triazine, as well as C(1)-C(2)-fused isoxazoles. The semi-synthetic compounds were screened for their cytotoxic...
Paper Details
Title
Preparation of novel ring-A fused azole derivatives of betulin and evaluation of their cytotoxicity
Published Date
Jan 1, 2017
Volume
125
Pages
629 - 639
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