Validation of signal impact assessment tool in order to explore pharmacovigilance signals' follow-up actions

Background: To determine which actions are advisable for signals arising from a spontaneous reporting system, the Netherlands Pharmacovigilance Centre Lareb uses a Signal Impact Assessment Tool (SIAT). It categorizes signals into one of four categories: strong/moderate signal strength and similarly health impact. This SIAT has not been validated yet. For a study which explored follow-up actions of pharmacovigilance signals, a validated tool was...