La hidroxicloroquina, un fármaco potencialmente letal

Published on May 1, 2017in Medicina Intensiva2.491
· DOI :10.1016/J.MEDIN.2016.05.004
C. Merino Argumánez2
Estimated H-index: 2
,
I. Sáez de La Fuente2
Estimated H-index: 2
+ 3 AuthorsJ.A. Sanchez Izquierdo2
Estimated H-index: 2
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Abstract
References13
Newest
#1Paul B. McBeth (UBC: University of British Columbia)H-Index: 24
#2Perseus I. Missirlis (UBC: University of British Columbia)H-Index: 1
Last. Vinay Dhingra (UBC: University of British Columbia)H-Index: 14
view all 4 authors...
Introduction. Hydroxychloroquine (HCQ) overdose is rare and potentially deadly when consumed in large doses. Management of severe HCQ toxicity is limited and infrequently reported. This report presents the case of a massive ingestion of HCQ. Case Report. A 23-year-old female presents following an intentional ingestion of approximately 40 g of HCQ. Within six hours after ingestion, she developed severe hemodynamic instability resulting from myocardial irritability with frequent ventricular ectopi...
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#1Maude St-Onge (U of T: University of Toronto)H-Index: 9
#2Eddy Fan (U of T: University of Toronto)H-Index: 40
Last. Peter C. Coyte (U of T: University of Toronto)H-Index: 61
view all 5 authors...
Abstract Purpose Venoarterial extracorporeal membrane oxygenation represents an emerging and recommended option to treat life-threatening cardiotoxicant poisoning. The objective of this cost-effectiveness analysis was to estimate the incremental cost-effectiveness ratio of using venoarterial extracorporeal membrane oxygenation for adults in cardiotoxicant-induced shock or cardiac arrest compared with standard care. Materials and methods Adults in shock or in cardiac arrest secondary to cardiotox...
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#1Sébastien Champion (Paris Diderot University)H-Index: 7
#2Isabelle Malissin (Paris Diderot University)H-Index: 14
Last. F. Baud (Paris Diderot University)H-Index: 9
view all 7 authors...
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#1Naren Gunja (Children's Hospital at Westmead)H-Index: 14
#2Darren M. Roberts (Children's Hospital at Westmead)H-Index: 39
Last. Nicholas A. Buckley (Children's Hospital at Westmead)H-Index: 72
view all 8 authors...
Hydroxychloroquine overdose is infrequently reported and the majority of recommendations come from the greater experience with chloroquine poisoning. We report two cases of massive hydroxychloroquine poisoning (20 g in each case), both of which received advanced cardiac life support and a treatment regimen consisting of sodium bicarbonate, adrenaline and potassium. Both these patients survived beyond their initial rapid deterioration and cardiovascular collapse to be discharged from hospital wit...
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#1Bruno MégarbaneH-Index: 66
#2Nicolas DeyeH-Index: 33
Last. Frédéric J. BaudH-Index: 48
view all 3 authors...
Les intoxications aigues par cardiotropes sont a l'origine d'une morbidite importante et d'une mortalite incompressible, notamment parmi les jeunes. Leur incidence augmente actuellement. Le choc cardiogenique refractaire aux therapeutiques pharmacologiques ainsi que l'arret cardiaque inopine et refractaire aux manoeuvres de ressuscitation en sont les modes principaux de deces. La connaissance du mecanisme de l'etat de choc toxique est fondamentale pour conduire un traitement adapte. Le traitemen...
Summary There are consistent differences in cardiovascular state between acute illness in malaria and recovery that prolong the electrocardiographic QT interval and have been misinterpreted as resulting from antimalarial cardiotoxicity. Of the different classes of antimalarial drugs, only the quinolines, and structurally related antimalarial drugs, have clinically significant cardiovascular effects. Drugs in this class can exacerbate malaria-associated orthostatic hypotension and several have be...
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Resume Nous rapportons un cas d'intoxication massive a l'hydroxychloroquine ayant beneficie d'une assistance circulatoire par circulation extracorporelle peripherique (CEC). Il s'agit d'une intoxication medicamenteuse volontaire chez une femme âgee de 39 ans, par ingestion de 12 g d'hydroxychloroquine associee a du bromazepam, de la paroxetine et du zolpidem. La patiente a presente un coma hypotonique, une defaillance hemodynamique, des troubles du rythme ventriculaire graves, et une hypokaliemi...
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#1Chun-Yu Chen (Memorial Hospital of South Bend)H-Index: 2
#2Feng-Lin Wang (Memorial Hospital of South Bend)H-Index: 1
Last. Chih-Chuan Lin (Memorial Hospital of South Bend)H-Index: 4
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Background. Hydroxychloroquine (HCQ) is used for treatment of lupus erythematosus. The cardiac toxicity of HCQ has focused primarily on acute intoxication. We report a case of chronic use of HCQ associated with torsade de pointes. Case report. A 67-year-old female presented with acquired long QT interval syndrome with a refractory ventricular arrhythmia. She was receiving chronic therapeutic doses of HCQ for the treatment of lupus erythematosus. Torsades de pointes was diagnosed in the Emergency...
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Resume Introduction L’hydroxychloroquine est, comme la chloroquine, responsable d’un effet stabilisant de membrane et d’une hypokaliemie correlee a la gravite de l’intoxication. La correction de cette hypokaliemie peut exposer au risque d’arythmie ventriculaire. Observation Il s’agit, chez une patiente de 19 ans, d’une intoxication par 6 grammes d’hydroxychloroquine a l’origine d’une hypokaliemie profonde (1,5 mmol/L a l’admission en reanimation). Trente-six heures apres la correction de cette h...
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#1E. Reed Smith (WashU: Washington University in St. Louis)H-Index: 3
Abstract Ingestion of 1–2 tablets of chloroquine or hydroxylchloroquine is thought to predispose children under 6 years of age to serious morbidity and mortality. The actual risk to the toddler and appropriate guidelines for care remain unclear at a time when both medications are therapeutically utilized as anti-inflammatory agents in addition to their main use as anti-parasitics. A review of the literature and data from the American Association of Poison Control Centers reveals instances where ...
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Cited By5
Newest
#1Huilan ZhangH-Index: 1
#2Lu ChengH-Index: 1
Last. Aiping ZhangH-Index: 1
view all 5 authors...
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#1Kanako Noda (Kyoto Prefectural University of Medicine)H-Index: 1
#2Shinji Akioka (Kyoto Prefectural University of Medicine)H-Index: 6
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 31
view all 4 authors...
Hydroxychloroquine (HCQ) is an international-standard ‘anchor’ drug for treatment of systemic lupus erythematosus (SLE). After being approved in Japan half a century later in the Western countries,...
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BACKGROUND: Although chloroquine, hydroxychloroquine, and quinine are used for a range of medical conditions, recent research suggested a potential role in treating COVID-19. The resultant increase in prescribing was accompanied by an increase in adverse events, including severe toxicity and death. The Extracorporeal Treatments in Poisoning (EXTRIP) workgroup sought to determine the effect of and indications for extracorporeal treatments in cases of poisoning with these drugs. METHODS: We conduc...
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A pandemia causada pelo novo coronavirus (2019-nCoV) tem causado milhares de mortes, sendo buscadas vacinas ou tratamentos especificos Criancas nao tem apresentado alta gravidade Pretendeu-se identificar tratamentos disponiveis para a pediatria Realizou-se revisao bibliografica integrativa, incluindo estudos publicados entre o periodo de 1o de Janeiro e 24 de Abril de 2020, utilizando-se as palavras-chave: 2019-nCOV;COVID-19;SARS-CoV-2 e Pediatrics Foram pesquisados os bancos de dados PubMed, Pe...
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#1Guilherme Antonio de Souza Silva (UFPE: Federal University of Pernambuco)H-Index: 3
#2Suéllen Pedrosa da Silva (UFPE: Federal University of Pernambuco)H-Index: 2
Last. Cristiane Moutinho Lagos de Melo (UFPE: Federal University of Pernambuco)H-Index: 15
view all 9 authors...
Abstract Recently, in China, in 2019, a new type of disease has arisen caused by a new strain of coronavirus, the SARS-CoV-2 virus, considered extremely worrying due to its high infectivity power and the easy ability to spread geographically. For patients in general, the clinical features resulting from respiratory syndromes can trigger an asymptomatic condition. However, 25% of patients infected by SARS-CoV-2 can progress to severity. Pregnant women are an unknown field in this complex process,...
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