Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site
Abstract
HIV-1 vaccine design is informed by structural studies elucidating mechanisms by which broadly neutralizing antibodies (bNAbs) recognize and/or accommodate N-glycans on the trimeric envelope glycoprotein (Env). Variability in high-mannose and complex-type Env glycoforms leads to heterogeneity that usually precludes visualization of the native glycan shield. We present 3.5-Å- and 3.9-Å-resolution crystal structures of the HIV-1 Env trimer with...
Paper Details
Title
Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site
Published Date
Sep 12, 2016
Volume
23
Issue
10
Pages
906 - 915
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