SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing
Abstract
Trimethylation of histone H3K36 is a chromatin mark associated with active gene expression, which has been implicated in coupling transcription with mRNA splicing and DNA damage response. SETD2 is a major H3K36 trimethyltransferase, which has been implicated as a tumor suppressor in mammals. Here, we report the regulation of SETD2 protein stability by the proteasome system, and the identification of SPOP, a key subunit of the CUL3 ubiquitin E3...
Paper Details
Title
SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing
Published Date
Sep 9, 2016
Journal
Volume
45
Issue
1
Pages
92 - 105
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