Clinical relevance of the bile acid receptor TGR5 in metabolism
Volume: 5, Issue: 3, Pages: 224 - 233
Published: Mar 1, 2017
Abstract
The bile acid receptor TGR5 (also known as GPBAR1) is a promising target for the development of pharmacological interventions in metabolic diseases, including type 2 diabetes, obesity, and non-alcoholic steatohepatitis. TGR5 is expressed in many metabolically active tissues, but complex enterohepatic bile acid cycling limits the exposure of some of these tissues to the receptor ligand. Profound interspecies differences in the biology of bile...
Paper Details
Title
Clinical relevance of the bile acid receptor TGR5 in metabolism
Published Date
Mar 1, 2017
Volume
5
Issue
3
Pages
224 - 233
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