A comparison of long-term outcomes between narrow and broad QRS complex patients treated with cardiac resynchronization therapy.

Published on Jun 1, 2016in Acta Cardiologica1.718
· DOI :10.1080/AC.71.3.3152093
Lok Bin Yap2
Estimated H-index: 2
(NIH: National Institutes of Health),
S T B Nguyen (NIH: National Institutes of Health)+ 13 AuthorsRazali Omar17
Estimated H-index: 17
(NIH: National Institutes of Health)
Sources
Abstract
Introduction There are few registries for narrow QRSd ≤ 120 ms patients treated with cardiac resynchronization therapy (CRT). We report longterm outcomes for patients with narrow QRSd ≤ 120 ms comp...
References24
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#1Frits W. PrinzenH-Index: 74
#2Kevin VernooyH-Index: 32
Last. Angelo AuricchioH-Index: 82
view all 3 authors...
More than 2 decades of research has established the role of cardiac resynchronization therapy (CRT) in medically refractory, mild to severe systolic heart failure (HF) with abnormal QRS duration and morphology. CRT confers a mortality benefit, reduces HF hospitalizations, and improves functional outcome in this population, but not all patients consistently demonstrate a positive CRT response. The reported nonresponder rate ranges between 20% and 40%, depending on the response criteria used.1 Eff...
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#1Hailong Dai (Kunming Medical University)H-Index: 5
#2Xue-Feng Guang (Kunming Medical University)H-Index: 4
Last. Zhi-Cheng Xiao (Kunming Medical University)H-Index: 43
view all 3 authors...
We read with interest the article by Thibault et al.1 Their study was interrupted prematurely by the Data Safety and Monitoring Board because of futility and safety concerns. In our opinion, according to their experimental design, the results of the study are inevitable for several reasons. First, this study did not include mechanical dyssynchrony in eligibility criteria. Several reports suggest that QRS duration is not correlated with …
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#1Michele BrignoleH-Index: 84
#2Angelo AuricchioH-Index: 82
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2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy : The Task Force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA)
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#1Arthur J. Moss (URMC: University of Rochester Medical Center)H-Index: 121
The physiological underpinning for cardiac resynchronization therapy (CRT) began with Carl Wiggers in 1925. He showed that when contraction of the heart was induced by direct cardiac electric stimulation, the early phase of contraction of the heart was slowed and myocardial tension developed more gradually.1 Wiggers explained these findings by differences in the order of excitation of the ventricle. Subsequent studies by a number of investigators highlighted the fact that a left bundle-branch bl...
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#1Bernard Thibault (MHI: Montreal Heart Institute)H-Index: 52
#2François HarelH-Index: 22
Last. Paul KhairyH-Index: 70
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Background— Although the benefits of cardiac resynchronization therapy are well established in selected patients with heart failure and a prolonged QRS duration, salutary effects in patients with narrow QRS complexes remain to be demonstrated. Methods and Results— The Evaluation of Resynchronization Therapy for Heart Failure (LESSER-EARTH) trial is a randomized, double-blind, 12-center study that was designed to compare the effects of active and inactive cardiac resynchronization therapy in pati...
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#7T. Bruce Ferguson (American Association for Thoracic Surgery)H-Index: 42
Last. Mark S. LinkH-Index: 83
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Developed in Collaboration With the American Association for Thoracic Surgery and Society of Thoracic Surgeons Andrew E. Epstein, MD, FACC, FAHA, FHRS, Chair ; John P. DiMarco, MD, PhD, FACC, FHRS; Kenneth A. Ellenbogen. MD, FACC, FAHA, FHRS; N.A. Mark Estes III, MD, FACC, FAHA, FHRS; Roger A.
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#1Tim Donahue (Ochsner Medical Center)H-Index: 2
#3Angel R. Leon (Emory University)H-Index: 35
Last. Esteem-Crt InvestigatorsH-Index: 2
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Previous studies suggest that CRT may benefit narrow QRS patients with mechanical dyssynchrony (MD). We conducted an acute and chronic study, evaluating the response of heart failure patients with a narrow QRS to cardiac resynchronization therapy (CRT). ESTEEM-CRT was a multi-center, single-arm, feasibility study that evaluated ICD-indicated, medically-optimized patients with EF ≤ 35%, NYHA class III heart failure, QRS duration <120 ms, and MD as defined by the standard deviation of time to peak...
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#1Paul W X Foley (Queen Elizabeth Hospital Birmingham)H-Index: 21
#2Kiran PatelH-Index: 27
Last. Francisco LeyvaH-Index: 22
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Objectives To evaluate the clinical response to cardiac resynchronisation therapy (CRT) in patients with heart failure and a normal QRS duration ( Setting Single centre. Patients 60 patients with heart failure and a normal QRS duration receiving optimal pharmacological treatment (OPT). Interventions Patients were randomly assigned to CRT (n=29) or to a control group (OPT, n=31). Cardiovascular magnetic resonance was used in order to avoid scar at the site of left ventricular (LV) lead deployment...
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#1Rutger J. van Bommel (LUMC: Leiden University Medical Center)H-Index: 32
#2C.J.W. Borleffs (LUMC: Leiden University Medical Center)H-Index: 6
Last. Jeroen J. Bax (LUMC: Leiden University Medical Center)H-Index: 152
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Aims Cardiac resynchronization therapy (CRT) improves cardiac function, heart failure symptoms, and prognosis in selected patients. Many baseline characteristics associated with heart failure may influence prognosis after CRT. The objective of this study was to evaluate the effect of several baseline characteristics in relation to long-term prognosis in heart failure patients treated with CRT. Methods and results A total of 716 consecutive heart failure patients treated with CRT were included in...
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#1Adam S. Fein (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 4
#2Yongfei Wang (Yale University)H-Index: 91
Last. Matthew R. Reynolds (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 81
view all 6 authors...
Objectives The purpose of the study was to define the extent and nature of cardiac resynchronization therapy (CRT) device usage outside consensus guidelines using national data. Background Recent literature has shown that the application of CRT in clinical practice frequently does not adhere to evidence-based consensus guidelines. Factors underlying these practices have not been fully explored. Methods From the National Cardiovascular Data Registry's Implantable Cardiac-Defibrillator Registry, w...
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