DNA methylation at birth within the promoter of ANRIL predicts markers of cardiovascular risk at 9 years

Robert Murray; Jennifer A Bryant; Phil Titcombe; Sheila J. Barton; Hazel Inskip; Nicholas C. Harvey; Cyrus Cooper; Karen A. Lillycrop; Mark A. Hanson; Keith M. Godfrey

doi:https://doi.org/10.1186/s13148-016-0259-5

doi.org/10.1186/s13148-016-0259-5

DNA methylation at birth within the promoter of ANRIL predicts markers of cardiovascular risk at 9 years

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..., Keith M. Godfrey

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Clinical Epigenetics5.70

Volume: 8, Issue: 1

Published: Sep 2, 2016

Abstract

Antisense non-coding RNA in the INK4 locus (ANRIL) fixed genetic variants have consistently been linked with coronary heart disease (CHD) risk. We investigated relationships between perinatal ANRIL promoter DNA methylation and CHD risk markers in children aged 9 years. Genetic variants in the non-coding RNA ANRIL identify it as an important CHD risk locus. Increasing evidence suggests that the early life environment may act through epigenetic...

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Paper Details

Title

DNA methylation at birth within the promoter of ANRIL predicts markers of cardiovascular risk at 9 years

DOI

doi.org/10.1186/s13148-016-0259-5

Published Date

Sep 2, 2016

Journal

Clinical Epigenetics

Volume

8

Issue

1

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