Cancer pain relief achieved by disrupting tumor-driven semaphorin 3A signaling in mice

Cancer-induced bone pain (CIBP) is the most common pain arising from cancer and is inadequately managed with current standard therapeutics. While the etiology of CIBP remains to be fully elucidated, increasing evidence suggests that CIBP is uniquely complex. We tested whether semaphorin 3A (Sema3A) signals were involved in the development of CIBP in mice. The mouse model employed for CIBP – mice inoculated with Lewis lung carcinoma (LLC) cells...