Age‐dependent effects of APOE ε4 in preclinical Alzheimer's disease

Volume: 3, Issue: 9, Pages: 668 - 677
Published: Aug 26, 2016
Abstract
The ε4 allele of apolipoprotein E (APOE) is the strongest known common genetic risk factor for Alzheimer's disease (AD) and alters age of onset in retrospective studies. Here, we longitudinally test the effects of APOE ε4 genotype and age during progression from normal cognition to AD.Using data from 5381 cognitively normal older individuals and Cox proportional hazards models, we longitudinally tested the effects of APOE genotype on progression...
Paper Details
Title
Age‐dependent effects of APOE ε4 in preclinical Alzheimer's disease
Published Date
Aug 26, 2016
Volume
3
Issue
9
Pages
668 - 677
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