Repetitive nerve stimulation as electrophysiologic biomarker in muscle cramps

Repetitive nerve stimulation (RNS) has been used to elicit muscle cramp, and the cramp threshold frequency has been proposed to well correlate with the occurrence of muscle cramps. Identification of after-discharges following RNS was also claimed to be useful for diagnosis of muscle cramps, but its role as an electrophysiologic biomarker of muscle cramps remains unclear. Frequency and severity of muscle cramp were measured by a patient-reported...