Structure, Function, and Evolution of Coronavirus Spike Proteins
Abstract
The coronavirus spike protein is a multifunctional molecular machine that mediates coronavirus entry into host cells. It first binds to a receptor on the host cell surface through its S1 subunit and then fuses viral and host membranes through its S2 subunit. Two domains in S1 from different coronaviruses recognize a variety of host receptors, leading to viral attachment. The spike protein exists in two structurally distinct conformations,...
Paper Details
Title
Structure, Function, and Evolution of Coronavirus Spike Proteins
Published Date
Sep 29, 2016
Journal
Volume
3
Issue
1
Pages
237 - 261
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