Recommendations on multiple testing adjustment in multi-arm trials with a shared control group
Volume: 27, Issue: 5, Pages: 1513 - 1530
Published: Sep 19, 2016
Abstract
Multi-arm clinical trials assessing multiple experimental treatments against a shared control group can offer efficiency advantages over independent trials through assessing an increased number of hypotheses. Published opinion is divided on the requirement for multiple testing adjustment to control the family-wise type-I error rate (FWER). The probability of a false positive error in multi-arm trials compared to equivalent independent trials is...
Paper Details
Title
Recommendations on multiple testing adjustment in multi-arm trials with a shared control group
Published Date
Sep 19, 2016
Volume
27
Issue
5
Pages
1513 - 1530
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