Phosphorylation of Farnesoid X Receptor at Serine 154 Links Ligand Activation With Degradation

Volume: 30, Issue: 10, Pages: 1070 - 1080
Published: Aug 29, 2016
Abstract
Comparison of 11 human nuclear receptor amino acid sequences revealed a conserved phosphorylation motif within their DNA-binding domains as an intramolecular signal that regulates proteolytic degradation. Nuclear receptors use this signal to either degrade or proscribe degradation through either the proteasome or nonproteasome pathways. A phosphomimetic farnesoid X receptor (FXR) S154D mutant neither bound to nor trans-activated an FXR-response...
Paper Details
Title
Phosphorylation of Farnesoid X Receptor at Serine 154 Links Ligand Activation With Degradation
Published Date
Aug 29, 2016
Volume
30
Issue
10
Pages
1070 - 1080
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