Longitudinal change in white matter in preterm infants without magnetic resonance imaging abnormalities: Assessment of serial diffusion tensor imaging and their relationship to neurodevelopmental outcomes

Published on Jan 1, 2017in Brain & Development1.504
· DOI :10.1016/J.BRAINDEV.2016.07.007
Satoshi Kidowaki5
Estimated H-index: 5
(Kyoto Prefectural University of Medicine),
Masafumi Morimoto21
Estimated H-index: 21
(Kyoto Prefectural University of Medicine)
+ 9 AuthorsHajime Hosoi33
Estimated H-index: 33
(Kyoto Prefectural University of Medicine)
Sources
Abstract
Abstract Purpose We used diffusion tensor imaging (DTI) to evaluate longitudinal changes in fractional anisotropy (FA) of white matter tracts in preterm infants without abnormal magnetic resonance imaging (MRI) findings. Imaging was conducted at term equivalent age (TEA) and 1 year of corrected age. Furthermore, we assessed correlations between FA and neurodevelopmental outcomes at 3 years of corrected age to investigate brain prematurity of preterm infants without MRI abnormalities. Methods Preterm infants underwent serial MRI at TEA and 1 year of corrected age. Of these, 13 infants entered a retrospective study, undergoing neurodevelopmental assessment at 3 years of corrected age. These infants were divided into two groups depending on gestational age (GA): Results FA of the splenium at TEA was significantly different between the two groups divided according to GA. However, this difference was no longer observed at 1 year of corrected age. There was no correlation between FA of the splenium at TEA and neurodevelopmental assessment scores at 3 years of corrected age. Conclusions At TEA, FA of the splenium was lower in younger GA infants without MRI abnormalities, but this may not affect subsequent neurodevelopmental outcomes.
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#1Linda S. de Vries (Boston Children's Hospital)H-Index: 59
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MRI is a neuroimaging technique which is increasingly being used in extremely preterm infants cared for on a level 3 neonatal intensive care unit. The technique was initially introduced in the 1980s in newborn infants with severe brain injury and was considered to be very useful for the prediction of especially motor outcome. Many centres have started to perform MRI routinely at discharge or term equivalent age (TEA) and have been able to show that subtle white matter abnormalities are better an...
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Introduction Recent diffusion tensor imaging (DTI) studies have demonstrated that leakage of hemosiderin into cerebrospinal fluid (CSF), which is caused by high-grade intraventricular hemorrhage (IVH), can affect cerebellar development in preterm born infants. However, a direct effect of low-grade IVH on cerebellar development is unknown. Thus, we evaluated the cerebellar and cerebral white matter (WM) of preterm infants with low-grade IVH.
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Abstract Introduction Visual impairment in preterm infants at term equivalent age (TEA) is associated with impaired microstructural development in the optic radiation, measured as reduced fractional anisotropy (FA) by Diffusion Tensor Imaging (DTI). We tested the hypothesis that these abnormalities develop during the late preterm period. Methods DTI was performed in 53 infants born at a median (range) of 30 +1 (25 +4 –34 +6 ) weeks post-menstrual age (PMA), 22 of whom were imaged twice. Results ...
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