Cardiac N-methyl d-aspartate Receptors as a Pharmacological Target

: This study focuses on characterization of the cardiac N-methyl d -aspartate receptors (NMDARs) as a target for endogenous and synthetic agonists and antagonists. Using isolated perfused rat hearts, we have shown that intracoronary administration of the NMDAR agonists and antagonists has a pronounced effect on autonomous heart function. Perfusion of rat hearts with autologous blood supplemented with NMDAR agonists was associated with induction...