N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells
Abstract
During mesenchymal development, the microenvironment gradually transitions from one that is rich in cell-cell interactions to one that is dominated by cell-ECM (extracellular matrix) interactions. Because these cues cannot readily be decoupled in vitro or in vivo, how they converge to regulate mesenchymal stem cell (MSC) mechanosensing is not fully understood. Here, we show that a hyaluronic acid hydrogel system enables, across a physiological...
Paper Details
Title
N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells
Published Date
Dec 1, 2016
Journal
Volume
15
Issue
12
Pages
1297 - 1306
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