[1,2]Oxazolo[5,4- e ]isoindoles as promising tubulin polymerization inhibitors
Abstract
A series of [1,2]Oxazolo [5,4-e]isoindoles has been synthesized through a versatile and high yielding sequence. All the new structures showed in the 1HNMR spectra, the typical signal in the 8.34-8.47 ppm attributable to the H-3 of the [1,2]oxazole moiety. Among all derivatives, methoxy benzyl substituents at positions 3 and 4 or/and 5 were very effective in reducing the growth of different tumor cell lines, including diffuse malignant peritoneal...
Paper Details
Title
[1,2]Oxazolo[5,4- e ]isoindoles as promising tubulin polymerization inhibitors
Published Date
Nov 1, 2016
Volume
124
Pages
840 - 851
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