Cellular Reorganization during Mitotic Entry

Temporal and spatial regulation of the small GTPase RhoA is a key element in triggering the disintegration of focal adhesions and the assembly of the actomyosin cortex during mitotic entry. Mitotic rounding generates optimal cell geometry for spindle assembly. The increase in cell volume and hydrostatic cell pressure generate forces against the environment of the cell. Cellular organelles undergo drastic and rapid changes in organization, shape,...