Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

Emerging evidence indicates that the inflammatory mechanisms involved in the pathophysiology of osteoarthritis (OA) differ from those in rheumatoid arthritis. This Review explores the mechanisms of chronic, low-grade inflammation in OA, discusses the evidence of their central role in its pathogenesis, and explores how they might be targeted to prevent or treat OA. Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage,...