Original paper

Cytoplasmic Drosha activity generated by alternative splicing

Pages: gkw668 - gkw668
Published: Jul 28, 2016
Abstract
RNase III enzyme Drosha interacts with DGCR8 to form the Microprocessor, initiating canonical microRNA (miRNA) maturation in the nucleus. Here, we re-evaluated where Drosha functions in cells using Drosha and/or DGCR8 knock out (KO) cells and cleavage reporters. Interestingly, a truncated Drosha mutant located exclusively in the cytoplasm cleaved pri-miRNA effectively in a DGCR8-dependent manner. In addition, we demonstrated that in vitro...
Paper Details
Title
Cytoplasmic Drosha activity generated by alternative splicing
Published Date
Jul 28, 2016
Pages
gkw668 - gkw668
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