Transplantation of tissue engineering neural network and formation of neuronal relay into the transected rat spinal cord
Abstract
Severe spinal cord injury (SCI) causes loss of neural connectivity and permanent functional deficits. Re-establishment of new neuronal relay circuits after SCI is therefore of paramount importance. The present study tested our hypothesis if co-culture of neurotrophin-3 (NT-3) gene-modified Schwann cells (SCs, NT-3-SCs) and TrkC (NT-3 receptor) gene-modified neural stem cells (NSCs, TrkC-NSCs) in a gelatin sponge scaffold could construct a tissue...
Paper Details
Title
Transplantation of tissue engineering neural network and formation of neuronal relay into the transected rat spinal cord
Published Date
Aug 5, 2016
Journal
Volume
109
Pages
40 - 54
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