A reduction in CD90 (THY-1) expression results in increased differentiation of mesenchymal stromal cells

Daniela Abreu de Moraes; Tatiana Tais Sibov; Lorena Favaro Pavon; Paula Queiroz Alvim; Raphael Severino Bonadio; Jaqueline Rodrigues da Silva; Aline Pic-Taylor; Orlando Ayrton de Toledo; Luciana Cavalheiro Marti; Ricardo Bentes Azevedo; D. M. Oliveira

doi:https://doi.org/10.1186/s13287-016-0359-3

doi.org/10.1186/s13287-016-0359-3

A reduction in CD90 (THY-1) expression results in increased differentiation of mesenchymal stromal cells

Daniela Abreu de Moraes

1

,

Tatiana Tais Sibov

10

,

..., D. M. Oliveira

18

Stem Cell Research & Therapy7.50

Volume: 7, Issue: 1

Published: Jul 28, 2016

Abstract

Mesenchymal stromal cells (MSCs) are multipotent progenitor cells used in several cell therapies. MSCs are characterized by the expression of CD73, CD90, and CD105 cell markers, and the absence of CD34, CD45, CD11a, CD19, and HLA-DR cell markers. CD90 is a glycoprotein present in the MSC membranes and also in adult cells and cancer stem cells. The role of CD90 in MSCs remains unknown. Here, we sought to analyse the role that CD90 plays in the...

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Paper Details

Title

A reduction in CD90 (THY-1) expression results in increased differentiation of mesenchymal stromal cells

DOI

doi.org/10.1186/s13287-016-0359-3

Published Date

Jul 28, 2016

Journal

Stem Cell Research & Therapy

Volume

7

Issue

1

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