YY1 Regulates the Germinal Center Reaction by Inhibiting Apoptosis
Abstract
The germinal center (GC) reaction produces high-affinity Abs for a robust adaptive immune response. When dysregulated, the same processes cause GC B cells to become susceptible to lymphomagenesis. It is important to understand how the GC reaction is regulated. In this study, we show that transcription factor YY1 is required to maintain a robust GC reaction in mice. Selective ablation of YY1 significantly decreased in the frequency and number of...
Paper Details
Title
YY1 Regulates the Germinal Center Reaction by Inhibiting Apoptosis
Published Date
Sep 1, 2016
Journal
Volume
197
Issue
5
Pages
1699 - 1707
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