Original paper

Transition path theory analysis of c-Src kinase activation

Volume: 113, Issue: 33, Pages: 9193 - 9198
Published: Aug 1, 2016
Abstract
Nonreceptor tyrosine kinases of the Src family are large multidomain allosteric proteins that are crucial to cellular signaling pathways. In a previous study, we generated a Markov state model (MSM) to simulate the activation of c-Src catalytic domain, used as a prototypical tyrosine kinase. The long-time kinetics of transition predicted by the MSM was in agreement with experimental observations. In the present study, we apply the framework of...
Paper Details
Title
Transition path theory analysis of c-Src kinase activation
Published Date
Aug 1, 2016
Volume
113
Issue
33
Pages
9193 - 9198
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