Incidence, Epidemiology, Aetiology and Staging, Classification, Clinical Presentation/Signs and Symptoms, Diagnosis, Staging Procedures/Investigation

Published on Jan 1, 2016
· DOI :10.1007/978-3-319-29203-8_1
Davide Campana31
Estimated H-index: 31
,
Paola Tomassetti47
Estimated H-index: 47
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Abstract
Neuroendocrine tumours (NET) comprise a large variety of rare and heterogeneous tumours with an estimated incidence of 3–5/100,000/year. They can arise in virtually every internal organ, but mainly occur in the gastroenteropancreatic and bronchopulmonary systems. Gastrointestinal and pancreatic neuroendocrine tumours (GEP-NET) include various types of solid tumours arising from the secretory cells of the neuroendocrine cell system; they can occur anywhere along the gastrointestinal tract.
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References10
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#1Sascha Ansén (University of Cologne)H-Index: 28
#2Anne M. Schultheis (University of Cologne)H-Index: 28
Last. W. TimensH-Index: 1
view all 14 authors...
#1Dieter HörschH-Index: 24
#2Kurt Werner SchmidH-Index: 78
Last. Hans HoffmannH-Index: 37
view all 20 authors...
Neuroendocrine tumors (NETs; syn. carcinoid tumors) are highly or moderately differentiated neoplasms. They comprise a large variety of rare and heterogeneous tumors with an estimated incidence of 3-5/100,000/year. They can arise in virtually every internal organ, but mainly occur in the gastroenteropancreatic and bronchopulmonary systems. Around 25% of the NETs are localized in the bronchopulmonary system. Approximately 2% of all lung tumors are NETs. According to the World Health Organization ...
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#1Irvin M. Modlin (Yale University)H-Index: 85
#2Steven F. Moss (Brown University)H-Index: 64
Last. Mark Kidd (Yale University)H-Index: 69
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Abstract Neuroendocrine tumours (NETs) are increasing in both incidence and prevalence and, as a group, are more prevalent than either gastric, pancreatic, oesophageal or hepatobiliary adenocarcinomas, or any two of these cancers combined. Clinical awareness of the protean and intermittent symptoms of NETs (eg, sweating, flushing, diarrhoea, and bronchospasm) is critical for timely diagnosis; however, the classical carcinoid syndrome is relatively uncommon. The most useful diagnostic test for ga...
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: Neuroendocrine tumours (NET) diagnosis has represented a major challenge in the past decades. The introduction of somatostatin receptor scintigraphy in the diagnostic work-up led to a significant improvement of accuracy. However with the advent of positron emission tomography (PET) that presents a higher spatial resolution as compared to the gamma camera and an array of different radiotracers, it is now possible to image NET with an even higher accuracy. In fact, PET imaging of NET is a rapidl...
#1Fred T. BosmanH-Index: 74
WHO Classification of Tumours of the Digestive System - Libros de Medicina - Gastroenterologia oncologica - 128,25
#1York SpringerH-Index: 1
#1Ch. WittekindH-Index: 23
Tienda online donde Comprar TNM Classification of Malignant Tumours, 7th Edition al precio 47,25 € de C. Wittekind | Mary K. Gospodarowicz | Leslie H. Sobin, tienda de Libros de Medicina, Libros de Oncologia - Oncologia clinica
#1James C. YaoH-Index: 76
#2Manal M. HassanH-Index: 64
Last. Douglas B. Evans (University of Texas MD Anderson Cancer Center)H-Index: 117
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Purpose Neuroendocrine tumors (NETs) are considered rare tumors and can produce a variety of hormones. In this study, we examined the epidemiology of and prognostic factors for NETs, because a thorough examination of neither had previously been performed. Methods The Surveillance, Epidemiology, and End Results (SEER) Program registries were searched to identify NET cases from 1973 to 2004. Associated population data were used for incidence and prevalence analyses. Results We identified 35,618 pa...
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#1Irvin M. Modlin (Yale University)H-Index: 85
#2Mark Kidd (Yale University)H-Index: 69
Last. Michael D. Shapiro (Yale University)H-Index: 13
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Gastrointestinal (GI) carcinoids are ill-understood, enigmatic malignancies, which, although slow growing compared with adenocarcinomas, can behave aggressively. Carcinoids are classified based on organ site and cell of origin and occur most frequently in the GI (67%) where they are most common in small intestine (25%), appendix (12%), and rectum (14%). Local manifestations—mass, bleeding, obstruction, or perforation—reflect invasion or tumor-induced fibrosis and often result in incidental detec...
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#1Gregory Kaltsas (St Bartholomew's Hospital)H-Index: 72
#2G. Michael Besser (St Bartholomew's Hospital)H-Index: 29
Last. Ashley B. Grossman (St Bartholomew's Hospital)H-Index: 129
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Neuroendocrine tumors (NETs) constitute a heterogeneous group of neoplasms that originate from endocrine glands such as the pituitary, the parathyroids, and the (neuroendocrine) adrenal, as well as endocrine islets within glandular tissue (thyroid or pancreatic) and cells dispersed between exocrine cells, such as endocrine cells of the digestive (gastroenteropancreatic) and respiratory tracts. Conventionally, NETs may present with a wide variety of functional or nonfunctional endocrine syndromes...
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