Deficiency in matrix metalloproteinase-2 results in long-term vascular instability and regression in the injured mouse spinal cord
Abstract
Angiogenesis plays a critical role in wound healing after spinal cord injury. Therefore, understanding the events that regulate angiogenesis has considerable relevance from a therapeutic standpoint. We evaluated the contribution of matrix metalloproteinase (MMP)-2 to angiogenesis and vascular stability in spinal cord injured MMP-2 knockout and wildtype (WT) littermates. While MMP-2 deficiency resulted in reduced endothelial cell division within...
Paper Details
Title
Deficiency in matrix metalloproteinase-2 results in long-term vascular instability and regression in the injured mouse spinal cord
Published Date
Oct 1, 2016
Journal
Volume
284
Pages
50 - 62
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