Abstract 1806: TRIM24 is an oncogenic transcriptional activator in prostate cancer
Abstract
Androgen receptor (AR) signaling is a key driver of prostate cancer (PC). While androgen-deprivation therapy is transiently effective in advanced disease, tumors often progress to a lethal castration-resistant state (CRPC). We show that recurrent PC-driver mutations in SPOP stabilize the TRIM24 protein, which promotes proliferation under low androgen conditions. TRIM24 augments AR signaling, and AR and TRIM24 co-activated genes are significantly...
Paper Details
Title
Abstract 1806: TRIM24 is an oncogenic transcriptional activator in prostate cancer
Published Date
Jul 15, 2016
Journal
Volume
76
Issue
14_Supplement
Pages
1806 - 1806
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