Nanostructured Antagonist of Extrasynaptic NMDA Receptors
Abstract
Glutamatergic cytotoxicity mediated by overactivation of N-methyl-d-aspartate receptors (NMDARs) is implicated in numerous neurological disorders. To be therapeutically viable, NMDAR antagonists must preserve physiological role of synaptic NMDARs (sNMDARs) in synaptic transmission and block only excessive pathological activation of NMDARs. Here we present a novel NMDAR antagonist that satisfies this two-fold requirement by exploiting spatial...
Paper Details
Title
Nanostructured Antagonist of Extrasynaptic NMDA Receptors
Published Date
Aug 9, 2016
Journal
Volume
16
Issue
9
Pages
5495 - 5502
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