Structure and Lipid Binding Preferences of the Alternatively Translated Region of PTEN-Long

PTEN-Long is a 576-amino acid translational variant of phosphatase and tension homolog on chromosome ten (PTEN), a tumor suppressor gene and antagonist to phosphoinositide-3-kinase (PI3K) signaling. PTEN-Long (PTEN-L) exhibits an alternative translation region (ATR) with additional 173 N-terminal amino acids to the normal PTEN open reading frame. Several studies have demonstrated that PTEN-Long is secreted from cells, can exist outside the cell...