Abstract 3276: The tissue and cellular destination of therapeutic IgGs in glioblastoma
Abstract
Most patients with recurrent glioblastoma (GBM) are treated with bevacizumab, a humanized monoclonal antibody (mAb) that binds VEGF-A and inhibits its binding to VEGFR. Approximately 30% of GBM patients are non-responsive to bevacizumab and the underlying mechanism for the lack of response is not known. It has been assumed that bevacizumab solely targets circulating VEGF-A in blood. We hypothesized that bevacizumab and human IgGs in general gain...
Paper Details
Title
Abstract 3276: The tissue and cellular destination of therapeutic IgGs in glioblastoma
Published Date
Jul 15, 2016
Journal
Volume
76
Issue
14_Supplement
Pages
3276 - 3276
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