iRGD peptide conjugation potentiates intraperitoneal tumor delivery of paclitaxel with polymersomes

Volume: 104, Pages: 247 - 257
Published: Jul 21, 2016
Abstract
Polymersomes are versatile nanoscale vesicles that can be used for cytoplasmic delivery of payloads. Recently, we demonstrated that pH-sensitive polymersomes exhibit an intrinsic selectivity towards intraperitoneal tumor lesions. A tumor homing peptide, iRGD, harbors a cryptic C-end Rule (CendR) motif that is responsible for neuropilin-1 (NRP-1) binding and for triggering extravasation and tumor penetration of the peptide. iRGD functionalization...
Paper Details
Title
iRGD peptide conjugation potentiates intraperitoneal tumor delivery of paclitaxel with polymersomes
Published Date
Jul 21, 2016
Volume
104
Pages
247 - 257
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