Arginines Plasma Concentration and Oxidative Stress in Mild to Moderate COPD.

Published on Aug 1, 2016in PLOS ONE3.24
路 DOI :10.1371/JOURNAL.PONE.0160237
Angelo Zinellu33
Estimated H-index: 33
(University of Sassari),
Alessandro G. Fois20
Estimated H-index: 20
(University of Sassari)
+ 6 AuthorsCiriaco Carru39
Estimated H-index: 39
(University of Sassari)
Sources
Abstract
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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#1Ruth B. Caldwell (Georgia Regents University)H-Index: 69
#2Haroldo A. Toque (Georgia Regents University)H-Index: 23
Last. R. William Caldwell (Georgia Regents University)H-Index: 31
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Arginase has roots in early life-forms. It converts L-arginine to urea and ornithine. The former provides protection against NH 3 ; the latter serves to stimulate cell growth and other physiological functions. Excessive arginase activity in mammals has been associated with cardiovascular and nervous system dysfunction and disease. Two relevant aspects of this elevated activity may be involved in these disease states. First, excessive arginase activity reduces the supply of L-arginine needed by n...
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Abstract The spatiotemporal modification of specific cysteinyl residues in proteins has emerged as a novel concept in signal transduction. Such modifications alter the redox state of the cysteinyl thiol group, with implications for the structure and biological function of the protein. Regulatory cysteines are therefore classified as 'thiol switches'. In this review we emphasize the relevance of enzymes for specific and efficient redox sensing, evaluate prerequisites and general properties of red...
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#1Jeremy A. Scott (Lakehead University)H-Index: 29
#2MyLinh Duongh (McMaster University)H-Index: 1
Last. Hartmut GrasemannH-Index: 30
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l-Arginine metabolism including the nitric oxide (NO) synthase and arginase pathways is important in the maintenance of airways function. We have previously reported that accumulation of asymmetric dimethylarginine (ADMA) in airways, resulting in changes in l-arginine metabolism, contributes to airways obstruction in asthma and cystic fibrosis. Herein, we assessed l-arginine metabolism in airways of patients with chronic obstructive pulmonary disease (COPD). Lung function testing, measurement of...
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#1Jeremy A. Scott (Northern Ontario School of Medicine)H-Index: 29
#2Hartmut Grasemann (U of T: University of Toronto)H-Index: 30
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#1Silvia Carraro (UNIPD: University of Padua)H-Index: 28
#2Giuseppe Giordano (UNIPD: University of Padua)H-Index: 21
Last. Eugenio Baraldi (UNIPD: University of Padua)H-Index: 67
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Background Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor and uncoupler of nitric oxide synthase. By promoting the formation of peroxynitrite, ADMA is believed to contribute to several aspects of asthma pathogenesis (ie, airway inflammation, oxidative stress, bronchial hyperresponsiveness, and collagen deposition). The aim of the present study was to compare this mediator in healthy children and children with asthma using the completely noninvasive exhaled breath condensate (EBC) ...
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#1Mark McEvoy (University of Newcastle)H-Index: 52
#2Peter W. Schofield (University of Newcastle)H-Index: 31
Last. John Attia (University of Newcastle)H-Index: 93
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Funding: Funding provided by the University of Newcastle Strategic Initiative Fund. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgments We are grateful to The University of Newcastle for funding and to the men and women of the Hunter region who provided the information recorded.
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Chronic bronchitis (CB) is a common but variable phenomenon in chronic obstructive pulmonary disease (COPD). It has numerous clinical consequences, including an accelerated decline in lung function, greater risk of the development of airflow obstruction in smokers, a predisposition to lower respiratory tract infection, higher exacerbation frequency, and worse overall mortality. CB is caused by overproduction and hypersecretion of mucus by goblet cells, which leads to worsening airflow obstructio...
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#1Jeremy A. Scott (U of T: University of Toronto)H-Index: 29
#2Michelle L. NorthH-Index: 19
Last. Hartmut Grasemann (Hospital for Sick Children)H-Index: 32
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Rationale: Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide synthase (NOS) inhibitor that competes with l-arginine for binding to NOS. It has been suggested that ADMA contributes to inflammation, collagen deposition, nitrosative stress, and lung function in murine models.Objectives: To test the hypothesis that ADMA is increased in asthma and that NOS inhibition by ADMA contributes to airways obstruction.Methods: We assessed alterations of l-arginine, ADMA, and symmetric dimethyla...
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#1Hartmut Grasemann (U of T: University of Toronto)H-Index: 30
#2Suhail Al-SalehH-Index: 17
Last. Felix RatjenH-Index: 81
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Rationale: Airway nitric oxide is reduced in cystic fibrosis airways. Asymmetric dimethylarginine is an endogenous nitric oxide synthase inhibitor that may contribute to nitric oxide deficiency in cystic fibrosis.Objectives: To test the hypothesis that asymmetric dimethylarginine is increased in cystic fibrosis and contributes to nitric oxide deficiency and airway obstruction.Methods: The concentrations of asymmetric dimethylarginine, symmetric dimethylarginine, and l-arginine were measured in s...
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#1Edzard Schwedhelm (UHH: University of Hamburg)H-Index: 56
#2Rainer H. B枚ger (UHH: University of Hamburg)H-Index: 75
Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, is a marker of renal dysfunction progression, vascular complications and death. Levels of ADMA and levels of its isomer symmetric dimethylarginine (SDMA) are elevated in patients with kidney disease. In this Review, Schwedhelm and Boger provide an overview of the roles of both dimethylarginines in renal, cerebrovascular and cardiovascular disease, and discuss how the biological function of ADMA and SDMA could b...
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The respiratory system is continuously exposed to endogenous and exogenous oxidants. Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation of the airways, leading to the destruction of lung parenchyma (emphysema) and declining pulmonary function. It is increasingly obvious that reactive oxygen species (ROS) and reactive nitrogen species (RNS) contribute to the progression and amplification of the inflammatory responses related to this disease. First, we described ...
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Introduction null Within the pathogenesis of the chronic obstructive pulmonary disease (COPD) there are interactions between different inflammatory mediators that are enhanced during an exacerbation. Arginase is present in bronchial epithelial cells, endothelial, fibroblasts and alveolar macrophages, which make it a probable key enzyme in the regulation of inflammation and remodelling. We aimed to find a potential relationship between arginase activity, inflammatory mediators in COPD patients in...
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#1Lin-Xi HeH-Index: 1
#2Zhao-Hui Tang (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 4
Last. Wei-Hong Li (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 1
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Chronic obstructive pulmonary disease (COPD) is a serious public health concern worldwide. By 2040, 4.41 million people are estimated to expire annually due to COPD. However, till date, it has remained difficult to alter the activity or progress of the disease through treatment. In order to address this issue, the best way would be to find biomarkers and new therapeutic targets for COPD. DNA methylation (DNAm) may be a potential biomarker for disease prevention, diagnosis, and prognosis, and its...
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#1Elisabetta ZinelluH-Index: 19
#2Angelo Zinellu (University of Sassari)H-Index: 33
Last. Pietro Pirina (University of Sassari)H-Index: 26
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Introduction. Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by airflow limitation that is not fully reversible after inhaled bronchodilator use associated with an abnormal inflammatory condition. The biggest risk factor for COPD is cigarette smoking. The exposure to noxious chemicals contained within tobacco smoke is known to cause airway epithelial injury through oxidative stress, which in turn has the ability to elicit an inflammatory response. In fact, th...
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#1Angelo Zinellu (University of Sassari)H-Index: 33
#2Elisabetta ZinelluH-Index: 19
Last. Pietro Pirina (University of Sassari)H-Index: 26
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It is amply reported that patients with chronic obstructive pulmonary disease (COPD) have increased risk of cardiovascular disease (CVD). Recent evidence suggests that COPD patients have elevated concentrations of plasma homocysteine (Hcy), a transsulfuration pathway analyte that is commonly regarded as a CVD risk factor. We comprehensively investigated the plasma concentrations of transsulfuration pathway analytes, and their relationship with markers of oxidative stress and inflammation, to ide...
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#1Mohamed El-Shanshory (Tanta University)H-Index: 7
#2Nahed Mohammed Hablas (Tanta University)H-Index: 4
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Asymmetric dimethylarginine (ADMA) level may play a role in the pathogenesis of cerebrovascular stroke in Children with Sickle Cell Anemia (SCA). To assess the plasma level of ADMA in children with SCA and its correlation to cerebral blood flow. This is a cross sectional study was carried out on 30 children with homozygous SCA under follow up in the Out Patients Clinic, Pediatric Department at Tanta University Hospital and 30 healthy children as a control group. Both groups had undergone the fol...
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Purpose: No consensus has been reached regarding appropriate nutritional intervention and rehabilitation during early acute exacerbation of COPD (AECOPD). Given the individual differences in symptoms of AECOPD, patients should be classified by their pathology. For example, it is known that there are differences in the inflammatory response between AECOPD with and without bacterial infection. However, there have been few reports on AECOPD from a nutritional perspective. The aim of this study was ...
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#1Pietro Pirina (University of Sassari)H-Index: 26
#2Elisabetta ZinelluH-Index: 19
Last. Angelo Zinellu (University of Sassari)H-Index: 33
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Chronic obstructive pulmonary disease (COPD) is a major and increasing global health problem. Serotonin is a neurotransmitter that participates in several pulmonary functions and it has been involved in oxidative stress, which plays essential roles in the pathogenesis of COPD. The current study aimed at establishing the levels of circulating serotonin in COPD, and investigating eventual relations between serotonin and oxidative stress markers. Whole blood serotonin was assessed in 43 consecutive...
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#1Angelo Zinellu (University of Sassari)H-Index: 33
#2Alessandro G. Fois (University of Sassari)H-Index: 20
Last. Ciriaco Carru (University of Sassari)H-Index: 39
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Experimental evidence suggests that oxidative stress (OS) may increase the activity of arginine methylating enzymes that produce the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA). In addition, it is well documented that OS can significantly decrease the synthesis and/or activity of ADMA degrading enzymes, thus causing ADMA accumulation in biological fluids. Recent reports have focused on circulating methylated arginine concentrations in chronic obstructive pulmona...
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#1Panagiotis Paliogiannis (University of Sassari)H-Index: 23
#2Alessandro G. Fois (University of Sassari)H-Index: 20
Last. Angelo Zinellu (University of Sassari)H-Index: 33
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: The aim of this meta-analysis was to review the available evidence regarding the blood concentrations of the oxidative stress marker malondialdehyde (MDA) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. 14 studies were included in the meta-analysis (from inception to October 2017) with a total of 817 COPD patients and 530 healthy controls. Pooled MDA concentrations were significantly higher in patients with COPD than controls (standardized mean di...
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