Immunohistochemical analysis of IgA expression differentiates IgG4-related disease from plasma cell-type Castleman disease

Volume: 50, Issue: 1, Pages: 34 - 41
Published: Jul 20, 2016
Abstract
Plasma cell-type Castleman disease (PCD) is often encountered when differentiating IgG4-related disease (IgG4-RD). Given that serum IgA is often elevated in Castleman disease, we investigated whether IgA expression levels in histological specimens can be used to differentiate between the two diseases. Lymph node lesions obtained from 12 IgG4-RD and 11 PCD patients were analysed by immunohistochemistry with anti-IgG, -IgG4, and -IgA antibodies....
Paper Details
Title
Immunohistochemical analysis of IgA expression differentiates IgG4-related disease from plasma cell-type Castleman disease
Published Date
Jul 20, 2016
Volume
50
Issue
1
Pages
34 - 41
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