Use of In Vitro Assays to Assess Immunogenicity Risk of Antibody-Based Biotherapeutics.
Abstract
An In Vitro Comparative Immunogenicity Assessment (IVCIA) assay was evaluated as a tool for predicting the potential relative immunogenicity of biotherapeutic attributes. Peripheral blood mononuclear cells from up to 50 healthy naive human donors were monitored up to 8 days for T-cell proliferation, the number of IL-2 or IFN-γ secreting cells, and the concentration of a panel of secreted cytokines. The response in the assay to 10 monoclonal...
Paper Details
Title
Use of In Vitro Assays to Assess Immunogenicity Risk of Antibody-Based Biotherapeutics.
Published Date
Aug 5, 2016
Journal
Volume
11
Issue
8
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