Structural and functional basis of protein phosphatase 5 substrate specificity

Volume: 113, Issue: 32, Pages: 9009 - 9014
Published: Jul 27, 2016
Abstract
The serine/threonine phosphatase protein phosphatase 5 (PP5) regulates hormone- and stress-induced cellular signaling by association with the molecular chaperone heat shock protein 90 (Hsp90). PP5-mediated dephosphorylation of the cochaperone Cdc37 is essential for activation of Hsp90-dependent kinases. However, the details of this mechanism remain unknown. We determined the crystal structure of a Cdc37 phosphomimetic peptide bound to the...
Paper Details
Title
Structural and functional basis of protein phosphatase 5 substrate specificity
Published Date
Jul 27, 2016
Volume
113
Issue
32
Pages
9009 - 9014
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